11 Activation of extracellular signal-regulated kinase after ischemia-reperfusion is required for cardioprotection of sevoflurane-induced preconditioning
2009 Volume 72 Issue 1 Pages 44-45
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2009 Volume 72 Issue 1 Pages 44-45
Brief exposure to volatile anesthetics before prolonged ischemia exerts a cardioprotective effect. We investigated whether extracellular signal-regulated kinase (ERK) is involved in sevoflurane-induced preconditioning. Isolated perfused guinea pig hearts were subjected to 30min global ischemia and 120min reperfusion (CTL). Sevofluraneinduced preconditioning was elicited by administration of sevoflurane at one minimum alveolar concentration with 10min washout before ischemia (SEVO). Infarct size was significantly reduced in SEVO compared to CTL. Phosphorylation of ERK at 10min after reperfusion was significantly increased in SEVO compared with CTL. Activation of ERK plays an important role in sevoflurane-induced preconditioning. This work was supported in part by Grant 07-06 from Osaka Dental University Research Funds.
