口腔扁平上皮癌におけるNanogの細胞内局在と細胞周期の関連

渡辺 昌広; 大西 祐一; 南野 友希; 宇垣 吉秀; 井上 洋士; 伊達岡 聖; 山本 浩貴; 杉立 光史; 中嶋 正博; 覚道 健治

doi:10.18905/shikaigaku.75.1_1

Relevance of intracellular localization of Nanog to the cell cycle in oral squamous cell carcinoma

Masahiro Watanabe, Yuichi Ohnishi, Yuki Minamino, Yoshihide Ugaki, Hiroshi Inoue, Suguru Dateoka, Hirotaka Yamamoto, Mitsuchika Sugitatsu, Masahiro Nakajima, Kenji Kakudo

Author information

Masahiro Watanabe
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
Yuichi Ohnishi
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
Yuki Minamino
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
Yoshihide Ugaki
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
Hiroshi Inoue
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
Suguru Dateoka
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
Hirotaka Yamamoto
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
Mitsuchika Sugitatsu
Department of Dentistry and Maxillofacial Surgery, Osaka Red Cross Hospital
Masahiro Nakajima
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
Kenji Kakudo
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

Keywords: Nanog protein, Intracellular localization, Proliferation

JOURNAL FREE ACCESS

2012 Volume 75 Issue 1 Pages 1-5

DOI https://doi.org/10.18905/shikaigaku.75.1_1

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Abstract

The cancer stem cell of oral squamous cell carcinoma is reported to have relevance to growth, differentiation and proliferation of tumors. Nanog protein is one of the transcriptional factors of embryonic stem cells. Recent data suggest that the expression of Nanog is upregulated in tumor development. We investigated the expression and localization of Nanog protein in HSC 4, which is an oral squamous cell carcinoma cell line. The results showed that Nanog protein is located in the nuclei of cells in cell line. Furthermore, Nanog protein is translocated from the nucleium to the cytoplasm in a condition of dense culture. These findings suggest that Nanog protein is related to the proliferation of oral squamous cell carcinoma.

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