2012 Volume 75 Issue 1 Pages 6-11
Since 95% of Japanese diabetic patients have the type II variety, it is important to understand the relationship between this disease and perjodontal disease. We did enzyme-histochemical and immunohistochemical analyses of the osteoblast and osteoclast functions of normal rats and type II diabetes mellitus (DM) model rats. There were fewer alkaline phosphatase (ALP)-positive osteoblasts, fewer tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts, less receptor activator of NF-κB ligand (RANKL) expression, and more osteoprotegerin (OPG) expression on the alveolar bone surface on the root membrane side in Goto-Kakizaki (GK) rats than in Wistar rats. The differentiation capacity of osteoblasts themselves was attenuated in alveolar bone in non-obese type II DM, and the lack of efficient bone resorption by osteoclasts resulted in failure of bone formation, that is, a change in the balance of bone remodeling.
