A case of infantile myofibromatosis manifested as glossal tumor

Abstract

  Infantile myofibromatosis is a rare disease characterized by single or multiple mesenchymal tumors. The tumors are often found in the head and neck, and 88% of the patients are diagnosed before the age of two. The prognosis is considered poor when the tumor is multiple or involves internal organs. We report a case of infantile myofibromatosis with the chief complaint of glossoncus. The case was a two-month-old female; a decrease in nursing and defective weight gain were noticed three weeks after she was born. At the first visit to the hospital, a hard 10×4 mm tumor at the left base of the tongue was found. According to pathological study and close examination of the whole body, we diagnosed her with infantile myofibromatosis with metastasis in the cerebrum, cerebellum, cervix, skin, bilateral lungs, and bones. Chemotherapy with vinblastine (VBL) and methotrexate (MTX) produced complete regression, and no new tumor appeared. Therefore, the treatment was considered effective.