人工的制御系のそう入による生体自律機能の改変

抄録

In an effort to analyze and control the performance of biological autonomic system, a variety of control elements were introduced into appropriate sites along varied autonomic reflex loops as follows:
(1) The systemic arterial pressure regulatory reflex loop involving the carotid sinus pressoreceptor was opened at the systemic arterial pressure-intrasinual pressure coupling in order to introduce a pressure amplifier with variable gain and/or a delay element with variable length. With such control elements in the loop, the arterial pressure was satisfactorily stabilized against certain disturbances, but with certain kinds of the gain and delay factors, it was rendered unstable enough to precipitate into self-oscillation.
(2) Based on the servoanalysis of the cerebral ischemic pressor response, a bias pressure generator was inserted into the systemic arterial pressure-oerebral perfusion pressure coupling to bias the latter from the former so that the response may lapse into feedback oscillation. Replacement of the bias pressure generator by the Starling's resistance also caused a cycling of different nature.
(3) The closed loop respiratory reflex involving the lung stretch receptor and the vagal afferent impulses was opened by severing the vagi. Afferent stimulation given to the cut end with preliminarily set cycle and the same stimulation synchronized with the respiratery cycle provided open and closed loop controlling procedures of the respiration respectively.