Abstract
We propose a mathematical model of human thyroid gland regulating basal metabolism based on biochemical reaction in it. Parameter values appeared in the model are identified by means of the optimum parameter method. This model is taken into our previous model of a hypothalamus-anterior pituitary-thyroid system. Iodine treatment for Graves' disease can be simulated by use of the combined model.
It apparently is contradictory that the iodine keeps Graves' disease under control, nevertheless it is one of materials making the thyroid hormone. Clinical data on the interesting iodine effects could be well explained from computer simulations of this model. Other misregulations in the basal metabolism system also could be simulated by use of this model.
