Abstract
In response to heightened awareness of protecting the health of infants and fetuses, as shown by the Miami Declaration adopted in 1997 and the Dubai Declaration in 2006, various actions have been taken. The effect of exposure to toluene, which is a typical indoor air contaminant, on the cerebral nervous system of humans during development is now being studied, in addition to its well-known toxicity. When investigating the effects of volatile organic compounds such as toluene, it is essential to examine their dynamic behavior in the human body as well as their toxicity. However, such research on fetuses and newborns requires a simple method applicable to micro-samples. The solid phase micro extraction (SPME) method is one such technique and is effective. Detailed susceptibility studies on the vulnerability of immature individuals must be conducted in the future.
