2014 Volume 22 Pages 23-29
Silk fibroin from Bombyx mori silkworm has outstanding mechanical properties despite being spun from aqueous solution. Now, we have been developing several kinds of biomaterials, such as regeneration materials for bone, cornea and artificial blood vessel. In this paper, we present the applications of silk fibroins to tissue engineering. In the case of blood vessel regeneration, we have developed the small diameter vascular grafts made by silk fibroins. As results, the new grafts from silk fibroins have good patency, and these grafts were commonly covered with cells and platelets at 4 weeks after implantation.