Abstract
Vitiligo-like hypopigmentation occasionally occurring in patients with malignant melanoma (MM) is an unfully elucidated and important phenomenon, but exploration of its mechanism may be helpful for further development of melanoma treatment. Here, we present a case of metastatic MM showing complete remission following the development of systemic vitiligo. In our case, as a considerable number of lymphocytes infiltrated both the primary and metastatic lesions, an autoimmune response appears to have taken place. In addition, he developed vertebral osteomyelitis persisting for more than a year during the course of treatment. The two extraordinary conditions might contribute to achieving a complete eradication of the metastatic melanoma.[Skin Cancer (Japan) 2010 ; 25 : 141-144]
