Abstract
Bowenoid papulosis (BP) is a disease characterized by multiple brown-to-black papules on the genitalia, and by histological changes similar to Bowen's disease. Human papillomavirus (HPV) has been reported to induce BP. On the other hand, verrucous carcinoma (VC) is a distinct variant of squamous cell carcinoma (SCC), which is also assumed to be associated with HPV infection. According to the anatomical localization of the tumor, four types can be distinguished : (1) VC of the oral cavity, known as Ackerman carcinoma or oral florid papillomatosis ; (2) VC of the anogenital area, also known as giant condyloma of Buschke-Loewenstein ; (3) VC occurring predominantly on the sole, also known as epithelioma cuniculatum ; and (4) VC occurring in other sites. In this article, the etiological role of HPV is discussed in the development of BP and each type of VC.[Skin Cancer (Japan) 2010 ; 25 : 300-307]
