Abstract
Clinical and pathological characteristics of invasive Paget's disease with lymph nodes or distant metastases are reviewed from the author's past experience, as follows. Three autopsied cases are briefly presented. The presence of hematogenous spread and tumor thrombi are shown with pathology images. Several different patterns of lymphatic flow cause bilateral inguinal mets or hemilateral mets depending on the location of the primary tumor. Chemotherapy and radiation therapy, though palliative, prolong the survival duration. Some groups of patients rapidly develop invasive nodules and mets unexpectedly. Those cases that are diagnosed as in situ disease pathologically may develop mets later.[Skin Cancer (Japan) 2010 ; 25 : 308-316]
