Abstract
A 76-year-old Japanese woman presented with an erythematous lesion on the vulva which had been noticed about 2 years earlier and grown rapidly during the last 6 months. Physical examination revealed a nodule accompanied by erythematous plaque from the left large pudendal lip to the anus, and some swollen bilateral inguinal lymph nodes. Biopsy confirmed the diagnosis of subcutaneous invasion of extramammary Paget's disease. Computed tomography showed metastasis of bilateral inguinal and para-aortic lymph nodes. She was treated with local excision of the primary lesion, followed by weekly docetaxel and trastuzumab, as immunohistochemical examination revealed strongly HER2 positive. After 7 courses, lymph node metastasis disappeared with few adverse effects. Eight weeks after chemotherapy, the complete response had continued. The weekly docetaxel-trastuzumab combination chemotherapy can be a very effective and well-tolerated therapy for patients with HER-2-positive advanced extramammary Paget's disease.[Skin Cancer (Japan) 2010 ; 25 : 367-371]
