A case of eyelid and conjunctival squamous cell carcinoma effectively treated using TS-1 and topical 5-FU

Abstract

A 79-year-old Japanese woman, who was diagnosed with squamous cell carcinoma (SCC) of the right upper eyelid invading the bulbar conjunctiva, refused surgical therapy and initiated chemotherapy. In the present case, weekly intramuscular injection of peplomycin was not useful ; however, the combination of oral titanium silicate (TS)-1 plus topical fluorouracil (5FU) was effective for the tumor lesion. One year and 10 months after her first visit, the tumor was almost undetectable with only slight erythematous change without local enlargement, eye problems, and the development of distant metastasis and adverse events due to chemotherapy remaining. Non-surgical treatment using TS-1 and topical 5FU may be an option to maintain quality of life, especially in elderly patients with eyelid SCC infiltrating the surface of the eyeball.[Skin Cancer (Japan) 2018 ; 33 : 50-54]