2018 Volume 33 Issue 1 Pages 55-60
We report a case of primary cutaneous anaplastic large cell lymphoma (C-ALCL) in a 77-year-old woman that recurred 20 years after the initial diagnosis. She presented with erythema and erosion on her right hallux, which developed into a gangrenous ulcer. A sixth skin biopsy performed showed perivascular infiltration of atypical lymphocytes in the mid dermis, which were positive for the CD30 stain. A right inguinal node was observed to be involved (T2cN1M0). She received treatment with oral prednisolone (PSL) and methotrexate (MTX) and local radiation therapy, which were very effective. We reduced the dose of MTX owing to the development of MTX-induced pancytopenia. She showed recurrence of C-ALCL, and her treatment was changed to oral PSL and low-dose etoposide. She has shown no recurrence over 3 years using the current therapy. [Skin Cancer (Japan) 2018 ; 33 : 55-60]
