Malignant melanoma with tumor thrombus in the inferior vena cava secondary to metastatic renal hilar lymph nodes : A case report

Abstract

A 42-year-old Japanese man was referred to our hospital in September 2013 with a growing brown macule on his back. We diagnosed it as malignant melanoma. Histopathological examination of an excisional biopsy specimen showed that it measured 2.0 mm in thickness. Metastatic lesions were not observed on whole-body computed tomography or in sentinel lymph node biopsy specimens. Approximately 2 years postoperatively, computed tomography revealed pulmonary metastatic lesions, and he was administered nivolumab. However, renal hilar lymph node metastasis was observed, which continued to progress. In November 2017, he was referred to our hospital with severe bilateral lower leg edema. Contrast-enhanced computed tomography showed obvious invasion of the inferior vena cava by metastatic renal hilar lymph nodes. Tumor thrombus secondary to direct invasion of metastatic melanoma is rare. We report a rare case of a patient with this condition and additionally present a literature review.[Skin Cancer (Japan) 2018 ; 33 : 192-195]