A case of locally advanced cutaneous squamous cell carcinoma of the left groin treated with preoperative chemoradiation therapy containing low-dose cisplatin and 5-fluorouracil

Abstract

We report a case of locally advanced cutaneous squamous cell carcinoma of the left groin. A 63-year-old man presented with a painful tumor on the left groin, which he noticed 2 years ago without seeking medical attention. When he visited our hospital, he had a foul-smelling ulcerated tumor measuring 10×5×1cm. A biopsied specimen revealed squamous cell carcinoma. Computed tomography (CT) showed lymphadenopathy, which appeared to be adhering to the left femoral artery and vein. No distant metastases were detected using positron emission tomography-CT. We diagnosed him with stage IVA (T3N2M0) squamous cell carcinoma of the skin, and he was treated with chemoradiation therapy containing cisplatin and 5-fluorouracil together with electron beam irradiation without any serious adverse effects. After this series of therapy, the primary tumor and metastatic node showed partial regression and could be resected completely with sufficient margins.[Skin Cancer (Japan) 2018 ; 33 : 255-259]