Development of heart failure upon dabrafenib and trametinib administration in malignant melanoma : case report

Abstract

A 72－year－old woman presented to our department with a tumor on the right lumbar region in January 2019. The patient recounted that she had a black spot in that same region since childhood. An excisional biopsy was performed in November of the same year, and a pathological diagnosis of malignant melanoma was made. Her PET/CT also revealed metastasis to the right inguinal region and right external iliac lymph node, and in December, she underwent right inguinal region, external iliac bone, and closed lymph node dissection (Stage IIIC). Oral administration of Tafinlar and Mekinist was initiated as postoperative adjuvant therapy ; however, the patient complained of respiratory distress six months after initiation of oral administration, and a detailed examination revealed a decrease in her cardiac function. She was subsequently diagnosed with drug－induced heart failure, prompting discontinuation of Tafinlar and Mekinist, and hospitalization for the management of her symptoms. Herein, we report a case of drug－induced heart failure caused by oral administration of Tafinlar and Mekinist, including certain bibliographical considerations for such cases.[Skin Cancer (Japan) 2021 ; 36 : 149－152]