2024 Volume 39 Issue 2 Pages 152-156
A 65－year－old female presented with a brown macule on her left lower thigh. Seven months before the initial consultation, a tumor appeared within the brown macule. A previous physician resected and diagnosed the patient with malignant melanoma. Computed tomography revealed lymphadenopathy of the left external and common iliac arteries. Since the tumor was negative for both BRAF－V600E/K mutations, nivolumab treatment was initiated. However, after the first administration, the patient developed fever with thyroid and liver dysfunction and refused further nivolumab treatment. A cancer gene panel test of the excised primary lesion revealed an NRAS mutation, suggesting that the MEK inhibitor was effective. Treatment with binimetinib was initiated using the nonstandard medical expense budget of our hospital. Twelve weeks after administration, some of the metastatic lymph nodes shrank. [Skin Cancer (Japan) 2024 ; 39 : 152－156]
