2024 Volume 39 Issue 2 Pages 192-197
Intravascular large B－cell lymphoma (IVLBCL) is a subtype of diffuse large B－cell lymphoma, in which tumor cells selectively proliferate within blood vessels, resulting in a variety of abnormalities. For a definitive diagnosis, the presence of tumor cells needs to be confirmed by histopathological examination. In this study, we investigated the usefulness of random skin biopsy, performed in our department, for the definitive diagnosis of 33 suspected IVLBCL cases. We focused on whether patients with negative skin biopsy results were ultimately diagnosed with diseases other than IVLBCL. Of the 33 cases, five were positive and definitively diagnosed with IVLBCL, and 27 were negative, except for one deceased patient. Additionally, all were ultimately diagnosed with diseases other than IVLBCL. These results suggest that this test is highly specific, with a positive result indicating a definitive diagnosis of IVLBCL and a negative result indicating absence of IVLBCL. To improve the usefulness of random skin biopsy, the accuracy of this test must be improved. As a key point for biopsy, priority should be given to skin eruptions, such as senile hemangiomas at three collection sites, if possible, and specimens should be taken at a depth sufficient to include fat.[Skin Cancer (Japan) 2024 ; 39 : 192－197]
