Two cases of Bowen disease in the male anogenital area
2025 Volume 40 Issue 2 Pages 133-137
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2025 Volume 40 Issue 2 Pages 133-137
Case 1 involved a 69－year－old male who presented with a reddish penile plaque. Case 2 involved a 78－year－old male with a reddish scrotal nodule. Histopathological examination in both cases revealed full－thickness epidermal dysplasia characterized by abnormal keratinocytes and the presence of clumped cells. The lesions were completely excised under local anesthesia. DNA was extracted from paraffin－embedded tissue samples of excised lesions, and HPV－DNA testing was conducted. HPV type 16 was detected in Case 1, and HPV type 51 was detected in Case 2. Immunohistochemical analysis revealed strong expression of p16 protein in both cases, whereas p53 protein expression was negative. In cervical cancer, p16 overexpression is widely recognized as a surrogate marker of HPV infection. However, in Bowen’s disease, p16 overexpression does not reliably correlate with HPV infection. Recent studies suggest that the absence of p53 expression, rather than p16 status, may be more closely associated with HPV－related Bowen disease.[Skin Cancer (Japan) 2025 ; 40 : 133－137]
