2025 Volume 40 Issue 2 Pages 138-142
A 37－year－old male with Fanconi anemia presented with a red plaque on the right scrotum. Surgical resection with a 6 mm margin revealed histopathological features of Bowen’s disease, which is characterized by full－thickness proliferation of atypical keratinocytes. High－risk human papilloma virus (HPV) was not detected. Fanconi anemia is a genetic disorder involving defects in the FA/BRCA DNA repair pathway and is associated with an increased risk of cancer. Although cutaneous squamous and basal cell carcinomas are commonly reported in patients with Fanconi anemia, Bowen’s disease is rare. Previously, these cases were typically linked to sun－exposed areas or a high－risk HPV infection. This case is notable because the lesion developed at a sun－protected site and it was HPV－negative. These findings highlight the need for vigilant monitoring of patients with Fanconi anemia because Bowen’s disease may arise in atypical locations and it is independent of HPV infection.[Skin Cancer (Japan) 2025 ; 40 : 138－142]
