Abstract

A case of two malignant melanoma as developed on the right cheek and lower eyelid was reported. A 57-year-old man had a black nodule, 13mm in diameter, on the center of his cheek. Histopathology revealed a malignant melanoma, nodular type, Clark's level IV, 3.8mm in thickness. No metastasis was found. The wide excision, skin graft and chemotherapy plus topical injection of IFN-β were done.
Two years later, he found another black nodule, 3.5mm in diameter, on a right lower eyelid. Histology showed many melanoma cells within the epidermis, and a small number of tumor cells was present in papillary dermis. Besides, the epidermis was acanthotic, and many lymphocytes infiltrated around the tumor. After the differential diagnosis from epidermotropically metastatic malignant melanoma, this case was diagnosed as multiple malignant melanoma on face.