Abstract

We attemped a chemohormonal therapy with dacarbazine, nimustine hydrochloride, cisplatin, and an anti-estrogen agent tamoxifen (DAC-Tam therapy) in a patient with stageIV melanoma.
After 4 courses of the therapy, skin, lymph node and lung metastasis disappeared or markedly decreased in size. However, imperception of legs followed by rapidly ascending paralysis of lower extremities appeared due to massive spinal metastasis. The patient died 6 months after initiation of the treatment.
Although chemohormonal therapy using tamoxifen is effective for melanoma metastasis, central nervous system reccurence seems to be a major obstacle.