Abstract
A 81-year-old man with apocrine adeno-carcinoma arising in the scalp was reported. The lesion of alopecia had been noticed since birth but had enlarged progressively during the past several years. A tumor measuring 32×32×4mm was excised. A histological examination revealed adenocarcinoma composed of atypical cells with abundunt eosinophilic cytoplasm and a finding of decapitation in some parts of the tumor. The tumor cells were PAS (+) (with resistance to diastase), CEA (±), EMA (±), GCDFP-15 (+), cytokeratin 7 and 19 (+) .
Electronmicroscopically, the cells had polygonal nuclei with many clefts and clumped chromatins. The cytoplasm contained moderate amounts of enlarged roughendoplasmic reticulum cisternae, a varying number of secretary granules, and many pleomorphic mitochondoria. Based on these findings, typical apocrine adenocarcinoma was diagnosed. We considered that this tumor was probably of apocrine origin associated with organoid nevus. [Skin Cancer (Japan) 2001; 16: 242-246]
