Abstract
A 75-year-old female was referred to our clinic in 1996, because of erythematous pruritic papules and plaques distributed on her feet. The diagnosis of chronic type adult T-cell leukemia (ATL) was made by serological and histological examinations. She was treated with oral glucocorticoids and an anticancer agent, etoposide. In July 2001, her skin lesions and physical signs became worse. Serological examination revealed an elevation of serum calcium and alkaline phosphatase levels. Since hypercalcemia is one of the severe complications of acute crisis in ATL, combination chemotherapy with VCAP-AMP-VECP was employed. Although her physical signs improved after starting this chemotherapy began, it was difficult to control her skin eruptions. In October, sobuzoxane was finally prescribed for her intractable eruptions. Two week after starting sobuzoxane treatment, the skin eruptions disappeared dramatically. Complete remission of ATL is maintained with sobuzoxane alone. Sobuzoxane appears to be one of the most effective agents especially for ATL skin lesions. [Skin Cancer (Japan) 2003; 18: 193-197]
