Abstract
A 61-year-old Japanese man presented with a five-year history of erosive lesions in the genitals. Histological findings of the skin lesions confirmed the diagnosis of subcutaneous invasion of extramammary Paget's carcinoma, and computed tomography revealed metastases of bilateral inguinal and left external iliac lymph nodes. The patient was treated with palliative resection of the genitals and left inguinal lesion, followed by low dose FP (5-FU, CDDP) therapy and simultaneous radiation therapy with 89 Gy to the lymph nodes and 59 Gy to the skin lesion. After 3 courses of the combination therapy, partial response was obtained in the lymph node metastases. After 6 courses, however external iliac lymph nodes enlarged in size and the local recurrence of skin lesion was observed. Low dose FP therapy combined with radiotherapy might be one of the armamentaria for assisting prolonged survival in the patients with advanced extramammary Paget's carcinoma. [Skin Cancer (Japan) 2005; 20: 79-83]
