Abstract
The patient was a 64-year-old man. He had had erythema in the vulva for about 10 years. It spread gradually while nodes accompanied by ulcers developed. Surgery for skin tumor removal, skin grafting, and reconstruction of the urinary tract was performed.
Histopathological examination revealed Paget's cells in the epidermis, a papillary tumor focus that had proliferated from the superficial layer to the deep layer of the dermis, and a tumor focus comprised of squamous cells and signet-ring cells in the deep layer of the dermis. The tumor cells in the site of the papillary proliferation were positive for CAM5.2 and CEA staining and negative for GCDFP15. There was no decapitation secretion. Signet-ring cells were positive for PAS and CAM5.2 staining and squamous cells were negative for Ki-67 staining, which represents cell proliferation capacity. These findings suggest that Paget disease of the vulva progressed to papillary proliferation and squamous metaplasia in this patient. [Skin Cancer (Japan) 2005; 20: 75-78]
