Abstract
We report two cases who experienced acute myocardial infarction (AMI) related to the chemotherapy they received for melanoma. The first case was a 61-year-old female with hyperlipidemia. She developed AMI on the 9th day of the third chemotherapy course with conventional doses of dacarbazine, nimustine, cisplatin and tamoxifen (DAC-Tam) . Laboratory data showed a rapid increase in hyperlipidemia during the chemotherapy. Cisplatin and tamoxifen can increase serum lipids. The second case was a 69-year-old male who developed AMI on the first day of the second chemotherapy course with conventional doses of dacarbazine, nimustine, vincristine, interferon-beta (DAVFeron) . Enhanced CT, which was taken only 3 hours after the infusion of the dacarbazine and vincristine, revealed a thrombosis in the coronary artery. We suspect that the case of the AMI was closely associated with the chemotherapy, since this type of chemotherapy can induce hypercoagulation. [Skin Cancer (Japan) 2006; 21: 36-40]
