Two cases of primary cutaneous marginal zone B-cell lymphoma

Abstract

The first case was a 52-year-old woman who noticed multiple cutaneous nodules with erythema on her right cheek. The second case was a 19-year-old female who noticed cutaneous nodules on her upper arms. Histologically, there was a grenz zone in the upper dermis and nested-like or sheet-like proliferation of the centrocyte-like cells were around reactive lymphoid follicule. In case 2, there was proliferation of plasma cells at the periphery of the lymphocytic infiltration with chain restriction. Tumor cells were positive for CD20, and negative for CD5, CD10. The polymerase chain reaction method using DNA extracted from a paraffin section showed a rearrangement band of the IgH chain gene. In both cases, primary cutaneous marginal zone B-cell lymphoma was diagnosed. [Skin Cancer (Japan) 2006; 21: 345-349]