Abstract
A 51-year-old female presented with a black macule on the left sole. The tumor appeared in September, 2005 and the size gradually increased. She visited our hospital on August 26, 2005. A 30×20mm-sized irregular and non indurated black macule was identified during the first examination. The dermatoscopy showed a parellel ridge pattern. The histological analysis of the resected tumor showed atypical melanocytes in the basal layer epidermis. These atypical melanocytes were all HMB 45 positive. Based on these observations, we diagnosed the patient as having malignant melanoma in situ.
In addition, there were large black macules on the mucous membrane of the cheek, multiple small black macules on the palmoplantar, and black longitudinal streaks on the nail. Evidence of Peutz-Jeghers syndrome, gastrointestinal polyposis, gene and endocrine abnormality were not found. We diagnosed the patient as having Laugier-Hunziker-Baran syndrome. [Skin Cancer (Japan) 2006; 21: 363-367]
