Abstract
We report a case of clear-cell eccrine carcinoma. A 51-year-old man visited our department on September 18, 2007, with a red nodule in the medial heel area of the right foot that he had first noticed in January of the same year, and that had since rapidly enlarged. He had developed a nodule in the same area seven years previously, which had been resected by a nearby doctor. At this visit, examination revealed a red pedunculated mass measuring 40×35×15mm in size in the medial heel area of the right foot. The surface of the mass showed ulceration and necrosis. Thoracoabdominal CT and Ga scintigraphy revealed no evidence of metastasis. On October 1, resection of the tumor along with a part of the fascia was performed, with a margin of 1cm around the tumor. Biopsy of a palpable lymph node in the right inguinal region revealed no metastasis. Histopathological examination revealed nests of proliferating tumor cells with clear cytoplasm within the dermis, that showed dyskaryosis. Formation of vacuoles was observed within the cytoplasm and in the intercellular spaces, and differentiation into cuticular border cells was recognized. Immunostaining of the tumor cells revealed positive staining for broad-spectrum keratin, CEA and EMA, and negative staining for GCDFP 15, a staining pattern suggestive of eccrine carcinoma. At present, one year after the surgery, the patient remains well, with no evidence of tumor recurrence or metastasis. [Skin Cancer (Japan) 2008; 23: 394-399]
