A Case of Dermatomyositis with Positive Anti-CADM-140 Antibodies and Multiple Skin Ulcers

Abstract

A 41-year-old female initially presented with edematous erythema of the upper eyelids, and then erythema gradually appeared in hands, cheeks and trunk. Skin symptoms such as heliotrope rash and erythema as well as the findings on skin biopsy were consistent with dermatomyositis. However, there were no apparent muscle symptoms. The level of myogenic enzymes was within the normal range and anti-Jo-1 antibodies were negative on blood exam. Therefore, we considered that the patient had clinically amyopathic dermatomyositis (CADM). Thereafter, she complained of enhanced itching and presented skin ulcers and mild interstitial pneumonia (IP). In addition, the levels of myogenic enzymes increased. Anti-CADM-140 antibodies were detected. Skin eruptions and IP were resolved and the levels of myogenic enzymes were improved by combined administration of corticosteroids, cyclosporine and cyclophosphamide hydrate.Skin Research, 10: 214-219, 2011