Abstract
A 47-year-old man had erythema with swelling at sites of mosquito bites and high fever the day after receiving such bites on his legs. Three days after the bites, soya bean-sized blisters with hemorrhage, blackish crusts and purpura at the sites of the mosquito bites were observed in widespread edematous erythema. He also had fever and right inguinal lymphadenopathy. Anti-Epstein-Barr virus (EBV) viral capsid antigen (VCA) IgG and anti-EBV early antigen (EA) IgG levels were increased (×640 and ×20, respectively). EBV DNA copy number in the peripheral blood was 79 copies/μg DNA. Dense lymphocytic infiltrate with eosinophils was found in the dermis and subcutaneous adipose tissue. Infiltrating cells had no atypia and were barely positive for EBV-encoded small RNA (EBER)-1. We diagnosed him with adult-onset hypersensitivity to mosquito bites on the basis of characteristic cutaneous symptoms at the sites of the mosquito bites, fever, lymphadenopathy and laboratory data of EBV. We report this rare case of adult-onset hypersensitivity to mosquito bites.Skin Research, 12: 117-121, 2013
