Abstract
We present a case of recurrent hydroxyurea-induced ulcers on the feet and toes, even after discontinuation of hydroxyurea therapy. A 72-year-old man with a history of polycythemia vera had received hydroxyurea for 1 year and 7 months, but he developed a painful skin ulcer over the right lateral malleolus. He discontinued the hydroxyurea; however, skin ulcers spread to the heels, which did not respond to conventional topical therapies. Peripheral artery diseases, venous insufficiency, diabetes, mycobacterial infection, and collagen diseases were ruled out; the direct cytotoxic effect of hydroxyurea may result in fragility of the skin, leading to multiple skin ulcers by minor trauma or pressure.Skin Research, 12: 74-78, 2013
