Abstract
A 60-year-old woman suffering from left breast cancer was treated by chemotherapy with paclitaxel (Abraxane®). The day after the initial treatment, erythematous macules and papules with severe itching developed on her trunk and extremities. On the fifth day of rash, maculopapular erythemas with scales and excoriations covered her whole body except her face. Oral bepotastine besilate and topical betamethasone butyrate propionate were effective and the eruptions resolved in one week. The treatment with Abraxane® was restarted because she wanted to continue the chemotherapy. Although every treatment with Abraxane® induced similar eruptions, the tumor gradually decreased in size. The result of drug-induced lymphocyte stimulation test for paclitaxel was negative. This case was given a diagnosis of a maculopapular-type drug eruption caused by Abraxane® via a non-allergic mechanism. In a case of mild drug eruption with chemotherapy for cancer, continuation of medical treatment with the chemotherapy should be considered.Skin Research, 12: 79-82, 2013
