Abstract
Adapalene (Differine®) gel is a topical retinoid originally approved for the treatment of acne vulgaris. It has been reported that adapalene is effective for painful periungual inflammation induced by molecular target drugs. We present three cases of painful periungual inflammation that were alleviated by adapalene application. Two of these three cases were periungual inflammation of the toes induced by gefitinib (Iressa®) for lung cancer. The other was periungual inflammation of the fingers induced by cetuximab (Erbitux®) for metastatic colorectal cancer. The patients did not respond to the treatment with topical corticosteroid preparation. After 4 weeks of adapalene application, periungual granulomatous inflammation and pain were alleviated in all three cases.Skin Research, 12: 92-96, 2013
