2018 Volume 17 Issue 5 Pages 250-254
An 80-year-old woman received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP ＋ etoposide 20 years earlier for non-Hodgkin’s lymphoma, and this resulted in remission. Six years later, she developed acute promyelocytic leukemia and was administered alltrans retinoic acid＋chemotherapy. Four years later, a red skin nodule appeared on the sole of her left foot. The tumor was resected and was diagnosed as a poroma. One year later, she noticed a red skin nodule on her left leg and it was treated conservatively. However, the number of nodules increased and she was referred to our department. Six red, dome-shaped, 3 mm-10 mm skin nodules were observed on her face and limbs. All six skin nodules were histopathologically diagnosed as poromas. The development of multiple poromas is relatively rare, with reports on 24 cases in the literature. Since 2000, reports of multiple poromas have increased ; the majority of cases occurred several years after treatment for leukemia and/or lymphoma. We speculate that the possibledeposition of calcium phosphatewithin theacrosyringium cells associated with thetumorlysis syndrome or its precursor state may be related to the development of multiple poromas. Skin Research, 17 : 250-254, 2018
