Abstract
A fifty-eight year-old male first came to our hospital on November, 2001. Red-brown papules and nodules had appeared on his face since 1991, and then, on his chest and back since 1999. Indurated red-brown maculae and nodules had scattered mainly on his face, chest and back. Lymph nodes were palpable on his neck, axillae and inguinal area. Laboratory test showed anemia, hyperproteinemia, and polyclonal hypergammmaglobulinemia. Pathological examination of the skin revealed dense perivascular infiltration of mature plasma cells in the dermis, and there were similar findings in lymph node from neck and bone marrow. We diagnosed this patient as systemic plasmacytosis, and started oral prednisolone (40mg/day) therapy because of progressive worsening of anemia and serum total protein level. While the skin lesion was slightly improved, marked improvement of anemia and hyperproteinemia were achieved. We also discussed about the treatment of systemic plasmacytosis quoting recent reports.
