2022 Volume 21 Issue 1 Pages 15-19
A 66-year-old Japanese man had well-defined erythema and erosions on the left inguinal and the scrotum 10 years before. He visited his local doctor and was diagnosed with extramammary Paget’s disease (EMPD) by skin biopsy. The patient underwent tumor resection with a 1-cm margin and lymphadenectomy in the left inguinal region at our hospital. Histopathological examination revealed a diagnosis of EMPD pT2N2M0 Stage IIIb. One year and 3 months after surgery, FDG-PET/CT showed intra-abdominal metastasis, and monthly docetaxel therapy was initiated. No visceral metastasis was found ; however, dysarthria and dyskinesia of the left upper extremity were observed after 34 courses of monthly docetaxel treatment. Contrast-enhanced magnetic resonance imaging showed a solitary mass, which was clinically diagnosed as a brain metastasis of EMPD. Craniotomy and brain tumor resection were performed, because it was a solitary mass and he was suffering from neurological symptoms. His neurological symptoms improved after the surgery. We summarize previous case reports of EMPD with brain metastasis and discuss whether craniectomy and brain tumor resection are effective for improving quality of life in these patients. Skin Research, 21 : 15-19, 2022
