2022 Volume 21 Issue 1 Pages 20-26
Abstract : An 88-year-old man presented with an erythematous nodule measuring 25×20 mm on his right cheek at the initial examination, which was noticed 2 months previously. It was histopathologically diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunohistological examination revealed that the nodule was double-expressor lymphoma positive for bcl-2 and c-myc with a poor prognosis. Fluorodeoxyglucose-positron emission tomography/computed tomography revealed another lymphoma lesion in the maxillary paranasal sinus. Based on these results and due to his old age, hematologists in our hospital judged that standard combination chemotherapy for DLBCL was not suitable for him. However, due to the rapidly growing nodule, he had difficulty opening his right eye. Thus, oral administration of low-dose etoposide and surgical resection of the tumor was performed as palliative care. He received additional radiation therapy on his cheek and maxillary paranasal sinus. Thereafter, although some lesions in the maxillary paranasal sinus remain, he is alive with good performance status, showing no recurrence of lymphoma on his cheek. Surgical resection may be a treatment option for localized cutaneous lesions, although DLBCL is high grade and shows poor prognosis markers. Skin Research, 21 : 20-26, 2022
