Abstract
A 66-year-old man developed a skin ulcer after receiving intravenous drip infusions of gabexate mesilate to treat disseminated intravascular coagulation. Gabexate mesilate had been given at a dose of 2.5% continuously for 7 days from a vein of his left dorsal hand. Although the drug did not extravasate, erythema with edema appeared around the affected vein, and an undermining ulcer was formed along the erythema 4 days later. Intradermal testing showed positive reaction to gabexate mesilate (0.1% aq) at 24 hrs. Skin biopsy of the erythema with edema on his left dorsal hand showed phlebitis and panniculitis. The skin ulcer became smaller after topical injection of 0.4% dexamethasone sodium phosphate and 1% lidocaine, 4ml/day around the erythema for 20 days. About 80 days after the first treatment, the skin ulcer was completely epithelized.
