Abstract
We report a case of scleroderma-like reaction induced by TS-1®, a compound drug of tegafur. An 81-year-old man with recurrent oral cavity cancer was treated by TS-1®. Ten days after administration of TS-1®, he felt stiffness in his fingers. After 14 days, edematous erythema developped on the face. Skin stiffness on his forearms and fingers and around his mouth was recognized. Anti-nuclear antibody was 80-fold. Histopathology of skin biopsy specimen revealed fibrotic change in the deep dermis. After discontinuation of TS-1® and administration of prednisolone 20mg per day, progression of sclerotic change was arrested.
