Two Cases of Immediate-Type Hypersensitivity Caused by Oxaliplatin

Abstract

Oxaliplatin has become a pivotal drug as a part of FOLFOX4 chemotherapy against the colon cancer. Here we show two cases of colon-cancer-bearing females, both stricken by hypersensitive reaction just in a few-minute infusion of oxaliplatin. Case 1 : a 52 year-old female, having been attacked by dyspnea and itchiness in the hands at the seventh term of FOLFOX4, was proven clearly positive to oxaliplatin in intracutaneous test. Although a combination of dexamethasone, cetirizine and hydroxyzine were previously taken before the next term to prevent hypersensitivity, the crucial reaction was hardly circumvented. Case 2 : a 46-year old female, having been suffered from general urticaria at the ninth term, showed weakly but significantly positive in intracutaneous test. Rechallenge to her was canceled based on the experience of the previous case.