A Case of Lichenoid Drug Eruption Due to Methyldigoxin

Abstract

A 82-year-old male presented with violaceous papules on the trunk and extremities that had appeared 4 months after the oral administration with methyldigoxin for angina and arhythmia. A biopsy specimen obtained from a papule revealed vacuolar alteration of the basal layer of the epidermis, the presence of colloid bodies, and dense band-like infiltration of lymphocytes in the superficial dermis, all of which are characteristic of lichen planus. The lesions disappeared after discontinuation of the medication. Oral provocation test with methyldigoxin showed positive reaction.