Abstract
Besides having an inhibitory effect of chemical mediator release from mast cells, IPD has an inhibitory effect of Th2 cytokines (IgE production by IL-4 inhibition and eosinophil proliferation by IL-5 inhibition). We administered IPD to patients with atopic dermatitis and evaluated the blood levels of IgE and eosinophil counts. IPD significantly improved the severity of the skin, but did not influence the IgE production and eosinophil number. However, IPD potently decreased the levels of IgE in 2 patients with marked hyperimmunoglobulinemia E. These results suggest that IPD is markedly useful in a certain group of patients with atopic dermatitis.
