Evaluation of the Compound Perfume “Fleuri 981SA” from Patch Test Results

Abstract

An attempt to clarify the allergenicity of a compound perfume “Fleuri 981SA, Lot No.31987. 7802”, made by the Firmenich Co., Switzerland, was undertaken. Because it was ranked as the 12th worst substance out of the whole registered standard allergens and as the 5th worst one out of the fragrance materials at our clinic from patch test results in 1981. The incidence of positive reactions of the Fleuri 981 SA in patch test was 10/225 (4.4%) in 1981. This lot of compound perfumes is said to be added three other fragrance materials, that is, hydroxycitronellal, oil of ylang ylang and geraniol. Fleuri 981SA without any additional fragrance material just showed a positive ratio of 1/162 (0.6%) in simultaneous patch tests.
Thus, the incidence of positive reactions in patch tests was compared between 23 patients sensitive to Fleuri 981SA with additional perfumes and generally tested population about the 3 fragrance materials and benzyl salicylate as a control. It was found that the frequency of positive reactions to hydroxycitronellal and oil of ylang ylang was significantly higher in the former than in the latter.
The results obtained suggest that Fleuri 981SA will accelerate a percutaneous absorption of hydroxycitronellal and oil of ylang ylang as a vehicle, showing much higher sensitivity than the original base perfume.