抄録
As uniformly fortified human milk does not provide sufficient nutrition to ensure the optimal growth of preterm infants, individualized fortification （IF） is required. Two types of IF exist, including adjustable fortification （Adj F）, based on blood urea nitrogen levels, and targeted fortification （Targ F）, based on an analysis of the protein content in human milk. We aimed to clarify the effectiveness, ease, safety, and complications for very-low-birth-weight infants （VLBWIs） by comparing Adj F with Targ F in a neonatal intensive care unit. This is a randomized controlled study. VLBWIs were randomly divided into the Adj F （n＝23） and Targ F （n＝22） groups. The anthropometric data of corrected age, growth velocity, and plasma aminograms at 37 weeks were compared between the groups. The median gestational ages were 29.0 and 28.7 weeks in the Adj F and Targ F groups, respectively. In both groups, the first day of individualized human milk fortification was 7 days following full-strength fortification initiation. The anthropometric data, growth velocity, complications, and aminograms were not significantly different between the groups, nor were the plasma amino acid levels. The average nutritional protein and energy intake exhibited no difference between the groups. The Adj F and Targ F methods demonstrated comparable findings regarding anthropometric data, growth velocity, and plasma amino acids. Therefore, IF method may be selected on the basis of institutional protocols and feasibility.
