Abstract
Inhalation has been regarded as a promising method for systematic drug delivery as well as treatment of pulmonary diseases. However, difficulty in controlling the powder characteristics is one of the major problems in this field that prevents wide application of the inhalation technology. Herein, strategies to obtain highly dispersive powders are presented, in which it was achieved by both physical and chemical approaches. Notably, addition of wrinkle structures on the particle surface significantly improved the powder dispersity. This technique may enable development of carrier-free nanoparticle inhalation therapy.
