Effects of Various Nanoparticles on Human Cells: Cell Specificity and its Application

Abstract

Application fields of nanoparticles range from biomedicine such as imaging and drug delivery systems to various industrial products. Despite the rapid progress, the potential for nanotoxicity in human has not yet been established. Most methods for toxicity assessment were designed and standardized with chemical toxicology. The reliable toxicity test systems are needed. Here, we present an overview of current in vitro toxicity tests for nanoparticles risk assessment, and focus on genotoxicity, especially cell-specific genotoxicity and its application.