Abstract
Many formulation technologies have been developed to overcome low-solubility problem of drug candidates. Herein introduced is the application of the electrospray technology as a new option. This method can produce solid amorphous nanoparticles in one-step. Moreover, it can be operated under ambient condition. In the first part of this paper, effect of solution and operation parameters on the particle formation was extensively investigated using chitosan / acetic acid aqueous solutions. Solution viscosity and conductivity were the most important parameters to affect particle size and even the availability of the formulation. The scaled-up study was performed using 8-nozzle manifold, by which prednisolone formulation was prepared with poly (vinyl pyrrolidone) K90. Although the solution of low concentration was preferred to obtain small particles, that of high concentration was favored for effective amorphization. The coaxial nozzle was used to control the surface characteristic of the particle. Dissolution rate of griseofulvin was significantly enhanced by coating the surface by Eudragit L-100.
